Profusion of fibroblast foci in patients with idiopathic pulmonary fibrosis does not predict outcome
نویسندگان
چکیده
منابع مشابه
Migratory marker expression in fibroblast foci of idiopathic pulmonary fibrosis
BACKGROUND Fibroblast foci (FF) are considered a relevant morphologic marker of idiopathic pulmonary fibrosis/usual interstitial pneumonia (IPF/UIP), and are recognised as sites where fibrotic responses are initiated and/or perpetuated in this severe disease. Despite their relevance, the cellular and molecular mechanisms responsible for the formation of FF and their role in tissue remodelling a...
متن کاملThree-dimensional characterization of fibroblast foci in idiopathic pulmonary fibrosis
In idiopathic pulmonary fibrosis (IPF), the fibroblast focus is a key histological feature representing active fibroproliferation. On standard 2D pathologic examination, fibroblast foci are considered small, distinct lesions, although they have been proposed to form a highly interconnected reticulum as the leading edge of a "wave" of fibrosis. Here, we characterized fibroblast focus morphology ...
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BACKGROUND In Idiopathic pulmonary fibrosis (IPF) irreversibly progressive fibrosing parenchymal damage, leads to defects in mechanics and gas exchange, manifesting with disabling exertional dyspnea. Previous studies have shown a relationship between fibroblast foci (FF) profusion and severity and survival and a relationship between dyspnea grade and severity and outcome. We hypothesized a rela...
متن کاملHealth-related quality of life does not predict mortality in idiopathic pulmonary fibrosis.
BACKGROUND Although health-related quality of life (HRQL) has recently been considered to be an important outcome in clinical trials of idiopathic pulmonary fibrosis (IPF), its relationship with survival is unknown. OBJECTIVE To determine the prognostic significance of HRQL scores in IPF assessed with the SGRQ. DESIGN Eighty-seven consecutive patients with IPF, who had undergone evaluations...
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BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial pneumonia causing a loss of respiratory surface area due to a proliferative fibrotic response involving hyperplastic, hypertrophic, and metaplastic epithelium, cystic honeycomb change, septal expansion, and variable inflammation. Wnt (wingless) signaling glycoproteins are known to be involved in lung development and ti...
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ژورنال
عنوان ژورنال: Respiratory Medicine
سال: 2008
ISSN: 0954-6111
DOI: 10.1016/j.rmed.2008.01.012